Maria C. Essers
My specialty as a lab technician is in animal experimentation.
I worked on cancer models and kidney transplantations in rats and mice.
For the past 10 years, I have been involved on cardiovascular research in rats and now I work mainly in mice. My interest lies primarily on heart physiology. I am measuring ECG’s in anesthetized mice and isolated mouse hearts.
My main focus is how the different cardiac ion channels are involved in heart complications, such as myocardial infarction or heart arrhythmias. This can be done by using genetically modified mice, which have the same mutation in the ion channels as the one found in patients with cardiac problems, or by removing the ion channel from the heart.
I have always liked to work in a lab, especially the bench work and to learn new techniques. It keeps it interesting and challenging. Especially the work on TRPM4 and unravelling its mysteries, involving its function in the heart.
Further, I like to do sports (I practice a Japanese sword art called “iaido”) and hike in the mountains or touring on the motorbike.
On the Web
Evidence for an important role of neutrophils in the efficacy of photodynamic therapy in vivo. de Vree WJ, Essers MC, de Bruijn HS, Star WM, Koster JF, Sluiter W. Cancer Res. 1996 Jul 1;56(13):2908-11.
Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). Kuin A, Aalders M, Lamfers M, van Zuidam DJ, Essers M, Beijnen JH, Smets LA. Br J Cancer. 1999 Feb;79(5-6):793-801.
Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat. Joosten SA, van Dixhoorn MG, Borrias MC, Benediktsson H, van Veelen PA, van Kooten C, Paul LC. Am J Pathol. 2002 Apr;160(4):1301-10.
PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. Shy D, Gillet L, Ogrodnik J, Albesa M, Verkerk AO, Wolswinkel R, Rougier JS, Barc J, Essers MC, Syam N, Marsman RF, van Mil AM, Rotman S, Redon R, Bezzina CR, Remme CA, Abriel H. Circulation. 2014 Jul 8;130(2):147-60. doi: 10.1161/CIRCULATIONAHA.113.007852. Epub 2014 Jun 3.
Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current. Gillet L, Rougier JS, Shy D, Sonntag S, Mougenot N, Essers M, Shmerling D, Balse E, Hatem SN, Abriel H. Heart Rhythm. 2015 Jan;12(1):181-92. doi: 10.1016/j.hrthm.2014.09.057. Epub 2014 Nov 18.