Alexandre Bokhobza

Visiting postdoc

At present, I am participating in the implementation of Nanopore sequencing technology in Abriel’s group.

I have obtained my PhD thesis in molecular and cellular aspects of biology, entitled: “Study of ORAI protein remodeling with CRISPR and quantitative microscopy”, in January 2022. I have a background in molecular biology (with specialization in cloning and CRISPR technology), and microscopy (with specialization in FLIM-FRET microscopy). I am passionate about high-end technologies that give a better understanding of biological processes. Therefore, I find Nanopore sequencing technology fascinating. Through the sequencing of ion channels coding genes such as the CFTR or the TRPM4 gene, we are willing to use the patients’ genetic information to identify variations that might help in (1) establishing diagnostic or (2) determining the more suited therapy/treatment.

 In my spare time, I enjoy discovering the wonders of Switzerland during hikes

  

On the Web

Email: alexandre.bokhobza@ibmm.unibe.ch

Institute of Biochemistry and Molecular Medicine

(ORCID 0000-0001-7953-4328)

Publications

TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and other Epithelial Cancer Cells. Giorgia Chinigò, Guillaume P. Grolez, Madelaine Audero, Alexandre Bokhobza, Michela Bernardini, Julien Cicero, Robert-Alain Toillon, Quentin Bailleul, Luca Visentin, Federico Alessandro Ruffinatti, Guillaume Brysbaert, Marc F. Lensink, Jerome De Ruyck, Anna Rita Cantelmo, Alessandra Fiorio Pla and Dimitra Gkika. Cancers 2022, 14(9), 2261. doi.org/10.3390/cancers14092261

Impact of Soce Abolition by Orai1 knockout on the proliferation, adhesion, and migration of hek-293 cells. Bokhobza, A., Ziental-Gelus, N., Allart, L., Iamshanova, O., Abeele, F.V. Cells, 2021, 10(11), 3016. doi.org/10.3390/cells10113016

Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation. Borowiec AS, Sion B, Chalmel F, D Rolland A, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, Jégou B, Prevarskaya N, Bidaux G. FASEB J. 2016 Sep;30(9):3155-70. doi: 10.1096/fj.201600257R. Epub 2016 Jun 17. PMID: 27317670 

Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Bidaux G, Borowiec AS, Dubois C, Delcourt P, Schulz C, Vanden Abeele F, Lepage G, Desruelles E, Bokhobza A, Dewailly E, Slomianny C, Roudbaraki M, Héliot L, Bonnal JL, Mauroy B, Mariot P, Lemonnier L, Prevarskaya N. Oncotarget. 2016 May 17;7(20):29063-80. doi: 10.18632/oncotarget.8666.

TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, Bokhobza A, Bidaux G, Degerny C, Verreman K, Guarmit B, Benahmed M, de Launoit Y, Bindels RJ, Fiorio Pla A, Prevarskaya N. J Cell Biol. 2015 Jan 5;208(1):89-107. doi: 10.1083/jcb.201402076.

TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion. Oulidi A, Bokhobza A, Gkika D, Vanden Abeele F, Lehen’kyi V, Ouafik L, Mauroy B, Prevarskaya N. PLoS One. 2013 May 31;8(5):e64885. doi: 10.1371/journal.pone.0064885. Print 2013.

PubMed List of Publications