Our research group is interested in ion channels and human diseases caused by dysfunction on ion channels, channelopathies.
We are part of the Institute of Biochemistry and Molecular Medicine at the University of Bern in Switzerland.
One of the principal objectives of our work is to elucidate novel molecular and cellular mechanisms of cardiac arrhythmias causing sudden cardiac death. To this end, on the one hand, our group investigates ion channel mutations found in patients and families presenting with genetic forms of lethal arrhythmias such as the congenital long QT syndrome, Brugada syndrome, or cardiac conduction disturbances. We are also interested in neurological channelopathies, in particular, the ones related to pain syndromes.
On the other hand, we are studying new types of regulation of cardiac ion channels relevant to arrhythmogenic mechanisms. Our group is currently investigating the regulation of the cardiac sodium channel Nav1.5 and its modulation by interacting proteins (funded by the Swiss National Science Foundation). Another focus is the TRP channel TRPM4 that is mutated in patients with cardiac conduction disorders. We are investigating the consequences of these mutations, as well as developing new small molecule modulators of TRPM4. This project was part of the NCCR TransCure (also funded by the Swiss National Science Foundation from 2010 until 2022).
Please have a look at our recently published original articles!
Our group is participating in the organization of the international channelopathy meeting series. The next meeting is scheduled in June 2024 in Montpellier, France. This meeting is following the Paris (2016) and Chicago (2018) meetings. More information on the website of the conference.
Hugues Abriel is co-organizing with Prof. Angelika Lampert (RWTH Aachen University, Germany) a series of online seminars entitled “Worldwide Sodium Channel Seminars”. The 2021-2022 series was very successful and please look at this link for the 2022-2023 program.