Our research group is interested in ion channels and human diseases caused by dysfunction on ion channels, channelopathies.
We are part of the Institute of Biochemistry and Molecular Medicine at the University of Bern in Switzerland.
One of the principal objectives of our work is to elucidate novel molecular and cellular mechanisms of cardiac arrhythmias causing sudden cardiac death. To this end, on the one hand, our group investigates ion channel mutations found in patients and families presenting with genetic forms of lethal arrhythmias such as the congenital long QT syndrome, Brugada syndrome, or cardiac conduction disturbances. We are also interested in neurological channelopathies, in particular, the ones related to pain syndromes and multiple sclerosis.
On the other hand, we are studying new types of regulation of cardiac ion channels relevant to arrhythmogenic mechanisms. Our group is currently investigating the regulation of the cardiac sodium channel Nav1.5 and its modulation by interacting proteins (funded by the Swiss National Science Foundation). Another focus is the TRP channel TRPM4 that is mutated in patients with cardiac conduction disorders. We are investigating the consequences of these mutations, as well as developing new small molecule modulators of TRPM4 in the framework of the NCCR TransCure (also funded by the Swiss National Science Foundation).
Please have a look at our recently published original articles!
Our group is participating in the organization of the next international channelopathy 2021 meeting in Québec City, Canada. This meeting is following the Paris (2016) and Chicago (2018) meetings. More information on the website of the conference.
In the frame of an academic sabbatical leave (Nov. 2020 – Aug. 2021), Hugues Abriel (principal investigator) is currently spending 10 months visiting French-speaking universities. More information on this link.