Please find below a list of our most recent (2016-2021) original articles. More articles are on EuroPMC, click here.

• Species-specific effects of cation channel TRPM4 small-molecule inhibitors. ARULLAMPALAM, P., PRETI, B., ROSS-KASCHITZA, D., LOCHNER, M., ROUGIER, J.-S., and ABRIEL, H. (2021) Front. Pharmacol. 12:712354. doi: 10.3389/fphar.2021.712354.
• Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation. HU, Y., ROSS-KASCHITZA, D., ESSERS, M., ARULLAMPALAM, P., FUJITA, T., ABRIEL, H., and INOUE, R. (2021)  Pflügers Archiv – European Journal of Physiology 473:507-519. doi:10.1007/s00424-020-02507-w.
• Deletion of Trpm4 alters the function of Nav1.5 in murine cardiac myocytes. OZHATHIL, L.C., ROUGIER, J.-S., ARULLAMPALAM, P., ESSERS, M.C., ROSS-KASCHITZA, D., and ABRIEL, H. (2021)  Int. J. Mol. Sci. 2021, 22(7), 3401. doi.org/10.3390/ijms22073401.
• Single-molecule localization of Nav1.5 reveals different modes of reorganization at cardiomyocyte membrane domains. VERMIJ, S.H., ROUGIER, J.-S., AGULLO-PASCUAL, E., ROTHENBERG, E., DELMAR, M., and ABRIEL, H. (2020). Circulation: Arrhythmia and Electrophysiology. doi: 10.1161/CIRCEP.119.008241.
• Biophysical Characterization of Epigallocatechin-3-gallate Effect on the Cardiac Sodium Channel Nav1.5. AMAROUCH, M.Y., MEHMET, H.K., DELEMOTTE, L., and ABRIEL, H. (2020) Molecules, 18;25(4):902. doi: 10.3390/molecules25040902.
• Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice. CASINI, S., ALBESA, M., WANG, Z., PORTERO, V., ROSS-KASCHITZA, D., ROUGIER, J.-S., MARCHAL, G.A., CHUNG, W.K., BEZZINA, C.R., ABRIEL., H., and REMME, C.A. (2019) Int. J. Mol. Sci. 2019, 20, 5033.
• Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by α-MHC but not TNT promoter. GILLET, L., GUICHARD, S., ESSERS, M.C., ROUGIER, J.-S., and ABRIEL, H. (2019) Sci Rep. Dec 19;9(1):19422.
• Modeling depolarization delay, sodium currents, and electrical potentials in cardiac transverse tubules. VERMIJ, S.H., ABRIEL, H., and KUCERA, J.P. (2019) Frontiers in Physiology, doi: 10.3389/fphys.2019.01487.
• A distinct pool of Nav1.5 channels at the lateral membrane of murine ventricular cardiomyocytes. ROUGIER, J.-S., ESSERS, M.C., GILLET, L., GUICHARD, S., SONNTAG, S., SHMERLING, D., and ABRIEL, H. (2019) Frontiers in Physiology, doi: 10.3389/fphys.2019.00834.
• Optimizing TRPM4 Inhibitors in the MHFP6 Chemical Space. DELALANDE, C., AWALE, M., RUBIN, M., PROBST, D., OZHATHIL, L.C., GERTSCH, J., ABRIEL, H., and REYMOND, J.-L. (2019) European Journal of Medicinal Chemistry. 166:167-177.
• Transcriptomic analyses of murine ventricular cardiomyocytes. CHEVALIER, M., VERMIJ, S.H., WYLER., K., GILLET, L., KELLER, I., and ABRIEL, H. (2018)  Scientific Data 5:180170 doi: 10.1038/sdata.2018.170, with corrigendum doi: 1038/sdata.2018.216.
• The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. BIANCHI, B., SMITH, P.A., and ABRIEL, H. (2018)  Molecular Brain. 11(1):41. doi: 10.1186/s13041-018-0385-4.
• Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells. TAMO, L., HIBAOUI, Y., KALLOL, S., ALVES, M., ALBRECHT, C., HOSTETTLER, K., FEKI, A., ROUGIER, J.-S., ABRIEL, H., KNUDSEN, L., GAZDHAR, A., and GEISER, T. (2018)  American Journal of Physiology-Lung Cellular and Molecular Physiology; doi: 10.1152/ajplung.00357.2017.
• Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. OZHATHIL, L.C., DELALANDE, C., BIANCHI, B., NEMETH, G., KAPPEL, S., THOMET, U., ROSS-KASCHITZA, D., SIMONIN, C., RUBIN, M., GERTSCH, J., LOCHNER, M., PEINELT, C., REYMOND, J.-L.#, and ABRIEL, H.# (#both senior authors) (2018) British Journal of Pharmacology, doi.org/10.1111/bph.14220.
• Four TRPM4 cation channel mutations found in cardiac conduction disease lead to altered protein stability. BIANCHI, B., OZHATHIL, L.C., MEDEIROS-DOMINGO A., GOLLOB, M.H., and ABRIEL, H. (2018) Frontiers in Physiology, 08 March 2018, doi.org/10.3389/fphys.2018.00177
• Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in intercalated discs. HICHRI, E., ABRIEL, H., and KUCERA, J.P. (2018) J. Physiol. 2018 Feb 15;596(4):563-589. Published with accompanying editorial.
• Annotation of functional impact of voltage-gated sodium channel mutations. HINARD, V., BRITAN, A., SCHAEFFER, M., ZAHN-ZABAL, M., THOMET, U., ROUGIER, J.-S., BAIROCH A., ABRIEL, H., and GAUDET P. (2017)  Human Mutation. May;38(5):485-493.
• The lateral membrane-specific MAGUK CASK down-regulates Nav1.5 channel in cardiomyocytes. EICHEL, C.A., BEURIOT, A., CHEVALIER, M.Y.E., ROUGIER, J.-S., LOUAULT, F., DILANIAN, G., AMOUR, J., COULOMBE, A., ABRIEL, H., HATEM, S.N., and BALSE, E. (2016)  Circulation Research, 119(4):544-556.
• A novel gain-of-function mutation in TRPM4 causes human progressive familial heart block type I. DAUMY, X., AMAROUCH, M.-Y., LINDENBAUM, P., BONNAUD, S., BIANCHI, B., BARON, E., FOUCHARD, S., THOLLET, A., KYNDT, F., BARC, J., LE SOUARNEC, S., LE MAREC, H., GOURRAUD, J.-B., PROBST, V., ABRIEL, H.#, REDON, R. #, SCHOTT, J.-J.# (#senior authors) (2016)  International Journal of Cardiology, 207:349-358.
• ICEPO: the Ion Channel ElectroPhysiology Ontology. HINARD, V., BRITAN, A., ROUGIER, J.-S., BAIROCH A., ABRIEL, H., GAUDET P. (2016)  Database (Oxford). Apr 7;2016. pii: baw017. doi: 10.1093/database/baw017.
• Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. SYAM, N., CHATEL, S.,  OZHATHIL, L.C., SOTTAS, V., ROUGIER, J.-S., BARUTEAU, A., BARON, E., AMAROUCH, M.Y., DAUMY, X., PROBST, V., SCHOTT, J.-J. ^#, and ABRIEL, H.^# (2016). (^#both senior authors)  Journal of the American Heart Association, May 20;5(5). pii: e001625.