Please find below a list of our most recent (2020–2026) publications. More articles are on Europe PMC, click here.
Original articles
2026
• El Makhzen N., Nater A., Rougier J.-S., Bokhobza A., Sanz J., Zweier C., Hämmerli A.-F., Bruggmann R., Bouguenouch L., Lakhdar Idrissi M., Abriel H.
CFTR gene variant detection in Moroccan individuals via nanopore long-read sequencing. Frontiers in Genetics 17:1769093. doi: 10.3389/fgene.2026.1769093.
• El Makhzen N., El Hejjioui B., Elmakhzen B., Bouramtane A., Bennis S., Bouguenouch L., Abriel H.
Long-read nanopore sequencing enhances BRCA1/2 variant detection compared with Ion Torrent analysis. Journal of Molecular Diagnostics 28(9):695-701. doi: 10.1016/j.jmoldx.2026.06.001.
• Guichard S., di Lorenzo E., Schneiter D., Essers M.C., Arullampalam P., Rougier J.-S., Abriel H.
Glycosylation of the murine cardiac channel TRPM4 is altered by the pathogenic p.I376T variant. Experimental Physiology 111(7):3294-3309. doi: 10.1113/EP093873.
• Iamshanova O., Hämmerli A.-F., Sundaralingam S., Seljmani A., Guichard S., Essers M.C., Rougier J.-S., Abriel H.
Biochemical assessment of α-α-subunit interactions of Nav1.5 in a heterologous expression system. Scientific Reports 16. doi: 10.1038/s41598-026-50463-9.
• Rougier J.-S., Glushkov E., Guichard S., Kučera J., Zeeb V., Abriel H.
All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level. Biophysical Journal 125(1):125-133. doi: 10.1016/j.bpj.2025.11.014.
2025
• Ekundayo B., Arullampalam P., Gerber C.E., Hämmerli A.-F., Guichard S., Boukenna M., Ross-Kaschitza D., Lochner M., Rougier J.-S., Stahlberg H., Abriel H., Ni D.
Identification of a binding site for small molecule inhibitors targeting human TRPM4. Nature Communications 16:833. doi: 10.1038/s41467-025-56131-2.
• Hämmerli A.-F., Ross-Kaschitza D., Arullampalam P., Shestak A., Juang J.J.-M., El Makhzen N., Soloaga Ricciardi B.S., Bokhobza A., Rougier J.-S., Zaklyazminskaya E.V., Gajek J., Hasdemir C., Abriel H.
Case Report: Loss-of-function TRPM4 mutation p.L91Δ implicated in progressive cardiac conduction defect. Frontiers in Physiology 16:1681438. doi: 10.3389/fphys.2025.1681438.
2024
• Iamshanova O., Hämmerli A.-F., Ramaye E., Seljmani A., Ross-Kaschitza D., Schärz N., Essers M., Guichard S., Rougier J.-S., Abriel H.
The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5. PLOS ONE 19(3):e0298820. doi: 10.1371/journal.pone.0298820.
2023
• Boukenna M., Rougier J.-S., Aghagolzadeh P., Pradervand S., Hämmerli A.-F., Pedrazzini T., Abriel H.
Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice. AJP Heart & Circulatory Physiology 324(4):H504-H518. doi: 10.1152/ajpheart.00671.2022.
• Selimi Z., Rougier J.-S., Abriel H., Kucera J.P.
A detailed analysis of single-channel Nav1.5 recordings does not reveal any cooperative gating. Journal of Physiology. doi: 10.1113/JP284861.
• Arullampalam P., Essers M.C., Boukenna M., Guichard S., Rougier J.-S., Abriel H.
Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice. Physiological Reports 11(16):e15783. doi: 10.14814/phy2.15783.
2022
• Dokshokova L., Franzoso M., Di Bona A., Moro N., Sanchez-Alonso J.L., Prando V., Sandre M., Basso C., Faggian G., Abriel H., Marin O., Gorelik J., Zaglia T., Mongillo M.
Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction. Journal of Physiology 600(12):2853-2875. doi: 10.1113/JP282828.
2021
• Hu Y., Ross-Kaschitza D., Essers M., Arullampalam P., Fujita T., Abriel H., Inoue R.
Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation. Pflügers Archiv – European Journal of Physiology 473:507-519. doi: 10.1007/s00424-020-02507-w.
• Ozhathil L.C., Rougier J.-S., Arullampalam P., Essers M.C., Ross-Kaschitza D., Abriel H.
Deletion of Trpm4 alters the function of Nav1.5 in murine cardiac myocytes. International Journal of Molecular Sciences 22(7):3401. doi: 10.3390/ijms22073401.
• Arullampalam P., Preti B., Ross-Kaschitza D., Lochner M., Rougier J.-S., Abriel H.
Species-specific effects of cation channel TRPM4 small-molecule inhibitors. Frontiers in Pharmacology 12:712354. doi: 10.3389/fphar.2021.712354.
2020
• Amarouch M.Y., Mehmet H.K., Delemotte L., Abriel H.
Biophysical characterization of epigallocatechin-3-gallate effect on the cardiac sodium channel Nav1.5. Molecules 25(4):902. doi: 10.3390/molecules25040902.
• Vermij S.H., Rougier J.-S., Agullo-Pascual E., Rothenberg E., Delmar M., Abriel H.
Single-molecule localization of Nav1.5 reveals different modes of reorganization at cardiomyocyte membrane domains. Circulation: Arrhythmia and Electrophysiology 13(7):e008241. doi: 10.1161/CIRCEP.119.008241.
• Wang Z.*, Vermij S.H.*, Sottas V., Shestak A., Ross-Kaschitza D., Zaklyazminskaya E.V., Hudmon A., Pitt G.S., Rougier J.-S., Abriel H.
Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5. Channels 14(1):268-286. doi: 10.1080/19336950.2020.1805999.
* shared first authorship
Reviews, protocols & perspectives
• Taib C., El Makhzen N., Abriel H. (2026)
Genetic research on cardiac channelopathies in African and African-descent populations: a scoping review. Journal of the American Heart Association 15(17). doi: 10.1161/JAHA.126.050282.
• Ratner L., Marangu D., Hamouda S., Kwarteng Owusu S., Eze J.N., Dakshi A., Wordui S.M., Hamdy A.M., Owusu S.A., Weldetsadik A.Y., Uluer A., Daimi H., El Makhzen N., Abriel H., Nasr S.Z., Moosa S., Swanson C., Cronin A.E., Zampoli M. (2026)
Characterising cystic fibrosis in African populations: a scoping review protocol on phenotype, diagnosis, genetics and barriers to care. BMJ Open 16(2):e110798. doi: 10.1136/bmjopen-2025-110798.
• Elmakhzen B., El Makhzen N., Abriel H. (2026)
Beta-thalassemia and a missing malaria landscape. Trends in Parasitology 42(2):87-88. doi: 10.1016/j.pt.2025.12.007.
• Ratner L., Abriel H., Helmers M., Uluer A., Cagnina R.E., Swanson C., Hennessy G., Weldetsadik A.Y., Owusu S.A., El Makhzen N., Kwarteng Owusu S., Wordui S.M., Uwineza A., Nasr S.Z., Zampoli M. (2025)
Developing a collaborative network for cystic fibrosis in Africa: a call to action. Journal of Cystic Fibrosis 24(5):825-829. doi: 10.1016/j.jcf.2025.08.013.
• Abriel H., Lampert A. (2025)
Voltage-gated sodium channels: mechanisms, disease, and a growing research community. Journal of General Physiology 157(6). doi: 10.1085/jgp.202513878.
• Sager F., Abriel H., Brönnimann M., Chan A., Mayer H., Richter V. (2025)
We’re all in this together: a rejoinder to Masud Husain’s (rant) editorial. Brain 148(5):e43-e44. doi: 10.1093/brain/awaf139.
Preprints
• Schneiter D., Rougier J.-S., Abriel H., Stahlberg H., Ekundayo B. (2026)
Temperature-dependent ligand relocation reveals plasticity of TRPM4 inhibition. bioRxiv Preprint. doi: 10.64898/2026.05.13.724805.
• Grunder F., Hämmerli A.-F., Bokembya C.I.N., Hennart S., Helmers M., Porret N.A., Graz B., Ouabo C.C., Abriel H. (2026)
A portable molecular laboratory for rapid genotyping in the field: application to sickle cell disease. medRxiv Preprint. doi: 10.64898/2026.05.05.26352080. Accepted in Frontiers in Genetics.
• El Makhzen N., Elmakhzen B., Bouguenouch L., Trhanint S., Bouzroud W., Abid H., Abriel H. (2025)
Long-read sequencing of the ATP7B gene from Moroccan patients with suspected Wilson disease. medRxiv Preprint. doi: 10.1101/2025.10.13.25337866. In revision.