Please find below a list of our most recent (2020-2025) original articles. More articles are on EuroPMC, click here

2025
• Ekundayo B., Arullampalam P., Gerber C.E., Haemmerli A., Guichard S., Boukenna M., Ross D., Lochner M., Rougier J., Stahlberg H., Abriel H., Ni D.
Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4. Nature Communications 16, 833. doi: 10.1038/s41467-025-56131-2.

• Rougier J.-S., Glushkov E., Guichard S., Kucera J., Zeeb V., Abriel H.
All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level. Biophysical Journal. S0006-3495(25)00749-0. doi: 10.1016/j.bpj.2025.11.014.

• El Makhzen N., Nater A., Rougier J.-S., Bokhobza A., Sanz J., Zweier C., Hämmerli A.-F., Bruggmann R., Bouguenouch L., Lakhdar Idrissi M., Abriel H.
CFTR gene variant detection in Moroccan individuals via Nanopore long-read sequencing. medRxiv Preprint. doi: 10.1101/2025.02.14.25322057.

• El Makhzen N., Elmakhzen B., Bouguenouch L., Trhanint S., Bouzroud W., Abid H., Abriel H.
Long-read sequencing of the ATP7B gene from Moroccan patients with suspected Wilson disease. medRxiv Preprint. doi: 10.1101/2025.10.13.25337866.

• Iamshanova O., Hämmerli A., Sundaralingam S., Seljmani A., Guichard S., Essers M., Rougier J.-S., Abriel H.
Biochemical assessment of α-α-subunit interactions of Nav1.5 in a heterologous expression system. bioRxiv Preprint. doi: 10.1101/2025.10.02.679760.

2024
• Iamshanova O., Häemmerli A.-F., Ramaye E., Seljmani A., Ross-Kaschitza D., Schäerz N., Essers M., Guichard S., Rougier J.-S., Abriel H.
The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5. PLOS ONE 19(3):e0298820. doi: 10.1371/journal.pone.0298820.

2023
• Boukenna M., Rougier J.-S., Aghagolzadeh P., Pradervand S., Haemmerli A.-F., Pedrazzini T., Abriel H.
Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice. AJP Heart & Circulatory Physiology 324(4):H504-H518. doi: 10.1152/ajpheart.00671.2022.

• Selimi Z., Rougier J.-S., Abriel H., Kucera J.P.
A detailed analysis of single-channel Nav1.5 recordings does not reveal any cooperative gating. Journal of Physiology. doi: 10.1113/JP284861.

• Arullampalam P., Essers M.C., Boukenna M., Guichard S., Rougier J.-S., Abriel H.
Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice. Physiological Reports 11(16):e15783. doi: 10.14814/phy2.15783.

2022
• Dokshokova L., Franzoso M., Di Bona A., Moro N., Sanchez-Alonso J.L., Prando V., Sandre M., Basso C., Faggian G., Abriel H., Marin O., Gorelik J., Zaglia T., Mongillo M.
Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction. Journal of Physiology 600(12):2853-2875. doi: 10.1113/JP282828.

2021
• Hu Y., Ross-Kaschitza D., Essers M., Arullampalam P., Fujita T., Abriel H., Inoue R.
Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation. Pflügers Archiv – European Journal of Physiology 473:507-519. doi: 10.1007/s00424-020-02507-w.

• Ozhathil L.C., Rougier J.-S., Arullampalam P., Essers M.C., Ross-Kaschitza D., Abriel H.
Deletion of Trpm4 alters the function of Nav1.5 in murine cardiac myocytes. International Journal of Molecular Sciences 22(7):3401. doi: 10.3390/ijms22073401.

• Arullampalam P., Preti B., Ross-Kaschitza D., Lochner M., Rougier J.-S., Abriel H.
Species-specific effects of cation channel TRPM4 small-molecule inhibitors. Frontiers in Pharmacology 12:712354. doi: 10.3389/fphar.2021.712354.

2020
• Amarouch M.Y., Mehmet H.K., Delemotte L., Abriel H.
Biophysical characterization of epigallocatechin-3-gallate effect on the cardiac sodium channel Nav1.5. Molecules 25(4):902. doi: 10.3390/molecules25040902.

• Vermij S.H., Rougier J.-S., Agullo-Pascual E., Rothenberg E., Delmar M., Abriel H.
Single-molecule localization of Nav1.5 reveals different modes of reorganization at cardiomyocyte membrane domains. Circulation: Arrhythmia and Electrophysiology 13(7):628-639, e008241. doi: 10.1161/CIRCEP.119.008241.

• Wang Z., Vermij S.H., Sottas V., Shestak A., Ross-Kaschitza D., Zaklyazminskaya E.V., Hudmon A., Pitt G.S., Rougier J.-S., Abriel H.
Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5. Channels 14(1):268-286. doi: 10.1080/19336950.2020.1805999.